COMPOSITIONS AND METHODS FOR TARGETING TYPE 1 INTERFERON PRODUCING CELLS

摘要

NZ 601760 Disclosed is the use of an immunoglobulin which binds an interleukin 3 receptor ? (IL-3R?) chain and competitively inhibits the binding of monoclonal antibody 7G3 to IL-3R? and which depletes or at least partly eliminates plasmacytoid dendritic cells (pDCs) and basophils to which it binds in the manufacture of a medicament for treating lupus in the mammal, wherein the immunoglobulin is not conjugated to a toxic compound that kills a cell to which the immunoglobulin binds, and wherein the immunoglobulin induces an enhanced level of enhanced effector function.