发明名称 |
Systems for Factor VIII Processing and Methods Thereof |
摘要 |
The present invention provides methods of reducing nonprocessed Factor VIII or a chimeric polypeptide comprising Factor VIII comprising co-transfecting in a host cell a polynucleotide encoding Factor VIII with a polynucleotide encoding a protein convertase, where the endogenous processing enzymes of the host cell are insufficient to convert all of the Factor VIII to its processed isoform; expressing a proprotein convertase from a second polynucleotide in the host cell; and reducing the nonprocessed Factor VIII by processing with said proprotein convertase.
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申请公布号 |
US2013281671(A1) |
申请公布日期 |
2013.10.24 |
申请号 |
US201113809285 |
申请日期 |
2011.07.11 |
申请人 |
PETERS ROBERT T.;LOW SUSAN C.;BIOGEN IDEC HEMOPHILIA INC. |
发明人 |
PETERS ROBERT T.;LOW SUSAN C. |
分类号 |
C07K14/755 |
主分类号 |
C07K14/755 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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