GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION
摘要
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
申请公布号
WO2013154728(A1)
申请公布日期
2013.10.17
申请号
WO2013US30836
申请日期
2013.03.13
申请人
THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
COLLINS, PETER, L.;LUONGO, CINDY, L.;BUCHHOLZ, URSULA, J.;MURPHY, BRIAN, R.