发明名称 |
NEW PHARMACEUTICAL COMPOSITIONS |
摘要 |
Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer. |
申请公布号 |
EP2648720(A2) |
申请公布日期 |
2013.10.16 |
申请号 |
EP20110805551 |
申请日期 |
2011.12.07 |
申请人 |
PEUHU, EMILIA;HOLMBOM, THOMAS;SJOEHOLM, RAINER |
发明人 |
ERIKSSON, JOHN;EKLUND, PATRICK |
分类号 |
A61K31/341 |
主分类号 |
A61K31/341 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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