| 摘要 |
FIELD: medicine.SUBSTANCE: invention refers to biotechnology, namely to a method for preparing aqueous dispersions of nanoparticles of a natural bark triterpenoid mixture. The method comprises dissolving the triterpenoid mixture in an organic solvent, bringing the triterpenoid solution into contact with water or an aqueous solvent solution, stirring the prepared mixture, processing with hexane for one-stage removal of excessive non-polar components and the solvent, separating a hexane phase from the dispersion of nanoparticles, removing the solvent and a major portion of water to form the aqueous dispersion of nanoparticles. Removing the non-polar components, such as betulin and lupeol, provides increasing a portion of the polar component betulin caffeate in the nanoparticles of the dispersion that leads to better dispersion prepared: improving monodispersity and morphological uniformity of the spherical amorphous nanoparticles.EFFECT: invention enables reducing the number of the production stages in the industrial production of the nanodispersions of the natural triterpenoid mixture and using the prepared nanoparticle dispersion without betulin caffeate pre-enrichment.4 dwg, 2 tbl, 3 ex |
