COMPOUNDS AND METHODS FOR INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS

摘要

PROBLEM TO BE SOLVED: To provide compounds useful for treating cancers, wherein the compounds bind to one or more Bcl proteins and block a Bcl anti-apoptotic function in cancer cells and tumor tissue that express the Bcl protein.SOLUTION: This invention relates to isoxazolidine-containing compounds typically represented by the following compound. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.