发明名称 |
IMMUNOTHERAPY USING ALLO-NKT CELLS, CELLS FOR IMMUNOTHERAPY IN WHICH alpha CHAIN OF T-CELL RECEPTOR (TCR) GENE HAS BEEN REARRANGED TO UNIFORM V alpha-J alpha , AND BANKING OF NKT CELLS DERIVED FROM SAID CELLS |
摘要 |
<p>The present invention provides an agent for an immunocyte therapy, comprising an NKT cell obtained by differentiating in vitro a cell having the ±-chain region of the T cell receptor gene rearranged to uniform V±-J± in an NKT cell receptor-specific way, wherein an administration subject is an allogenic individual having MHC gene loci including at least one locus having a genotype different from that of the NKT cell. In addition, the present invention provides a bank of a human cell or an NKT cell derived from said cell, wherein the ±-chain region of a T cell receptor (TCR) gene has been rearranged to uniform V±-J±. The agent and cell bank of the present invention are useful for the prophylaxis and/or treatment of cancer, infection, an allergic disease or an autoimmune disease.</p> |
申请公布号 |
EP2647384(A1) |
申请公布日期 |
2013.10.09 |
申请号 |
EP20110844377 |
申请日期 |
2011.12.02 |
申请人 |
RIKEN |
发明人 |
TANIGUCHI, MASARU;KOSEKI, HARUHIKO;WATARAI, HIROSHI;FUJII, SHIN-ICHIRO |
分类号 |
A61K35/14;A61K31/7028;A61K45/06;A61P31/00;A61P35/00;A61P37/06;A61P37/08;C07K14/725;C12N5/0783 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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