| 摘要 |
The present invention relates to: TNF-alpha antagonists containing IGFBP5 protein, variants thereof, or fragments thereof; and the use of the TNF-alpha antagonists. More specifically, the present invention relates to: a polynucleotide encoding the protein, variants thereof, or fragments thereof; a vector containing the polynucleotide; a transformant containing the vector; and a method for screening a therapeutic agent for TNF-alpha overexpression-related diseases by checking whether the mutual reaction thereof is facilitated after treating with candidates to the cell expressing the IGFBP5 protein, variants thereof, or fragments thereof, and the TNFR1.
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