发明名称 |
Detection of mutations in a gene associated with resistance to viral infection, OAS1 |
摘要 |
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
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申请公布号 |
US8551772(B2) |
申请公布日期 |
2013.10.08 |
申请号 |
US201113302081 |
申请日期 |
2011.11.22 |
申请人 |
IADONATO SHAWN P;MAGNESS CHARLES L;ROSENBERG GARY;SCHERER CHRISTINA A;GUILLAUDEUX THIERRY;KINETA TWO, LLC |
发明人 |
IADONATO SHAWN P;MAGNESS CHARLES L;ROSENBERG GARY;SCHERER CHRISTINA A;GUILLAUDEUX THIERRY |
分类号 |
C12N15/00;C07H21/04;C12N1/21;C12N9/12;C12N9/22;C12N15/869;C12Q1/68;C12Q1/70 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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