COMPOSITION FOR INDUCING DIFFERENTIATION OF MAMMARY EPITHELIAL CELL AND METHOD OF INDUCING DIFFERENTIATION OF MAMMARY EPITHELIAL CELL USING THE COMPOSITION

摘要

PURPOSE: A composition for inducing differentiation of mammary epithelial cells is provided to establish mammary alveolar cells (MAC-T) in which the expression of casein gene is increased by inducing differentiation of MAC-T and to establish a validation system for identifying the expression and the production of a target gene. CONSTITUTION: A composition for inducing differentiation of mammary epithelial cells contains retinoic acid as an active ingredient. The composition additionally contains prolactin. The mammary epithelial cells are derived from an animal selected among cattle, goat, and sheep. A method for inducing differentiation of mammary epithelial cells comprises the steps of: preparing mammary epithelial cells; and culturing the mammary epithelial cells in a medium containing retinoic acid as an active ingredient.