STABLE BORTEZOMIB FORMULATION

摘要

PROBLEM TO BE SOLVED: To provide a bortezomib formulation for multiple doses in which the stability of bortezomib is remarkably improved.SOLUTION: Bortezomib is in a liquid state that is appropriate for injection and its solvent system chiefly contains propylene glycol, in particularly preferable formulation. In other desirable embodiments, bortezomib is present as a Lewis donor-receptor complex formed with a hetero bifunctional Lewis base.