Method for diagnosing tuberculosis in a urine sample

摘要

A method of diagnosing tuberculosis disease or infection from a urine sample of a subject is provided, wherein the urine sample is tested for the presence of at least one Mycobacterium tuberculosis-specific biomarkers selected from Rv1475c, Rv1977, Rv0014c, Rv2748c, Rv1664, Rv1 161, Rv2280, Rv2694c, Rv2490c, Rv0578c, Rv1450c, Rv1522c, Rv2737c, Rv2981 c, Rv0765c, Rv2126c, Rv1759c, Rv1464, Rv3202c, Rv0668, Rv3345c, Rv3775, Rv3736, Rv2455c, Rv3885c and Rv1235. The method can distinguish active tuberculosis disease from latent tuberculosis infection. A point-of-care diagnostic device and a kit for use in the method are also provided.