METHOD FOR PRODUCING OPTICALLY ACTIVE FLUORINE-CONTAINING OXETEN

摘要

[Problem] To provide a practical production method by which an optically active fluorine-containing oxeten which can become an important intermediate for pharmaceuticals and agrochemicals is able to be stably isolated. [Solution] This method for producing an optically active fluorine-containing oxeten is characterized in that a fluorine-containing ±-ketoester and an internal alkyne are caused to react with each other in the presence of a transition metal complex that has an optically active ligand. By adopting the production method of the present invention, an optically active fluorine-containing oxeten can be obtained with high regioselectivity and high stereoselectivity (high optical purity) with high yield even in cases where the amount of an asymmetric catalyst is relatively low. In addition, the thus-obtained optically active fluorine-containing oxeten can be converted into various useful intermediates.