| 摘要 |
The invention is directed to a method of diagnosing a malignant ovarian tumor disease in a subject, which comprises -providing a sample of peripheral blood cells (PBC) of the subject, -measuring the expression of a multimarker gene panel comprising at least NEAT1, BC037918, C1 orf63, PRIC285, OSM, and optionally further genes or protein markers, and -comparing to a reference value, the differential expression being indicative of a malignant ovarian tumor, and a set of reagents to determine the expression of such a multimarker panel, as well as the use of a PBC-expression based test to improve the diagnosis of ovarian cancer. The invention further relates to a method of determining the expression of at least one of the RPL21, RPL9 and/or SH3BGRL3 genes in a PBC sample of a subject as internal control. |
