发明名称 |
Methods and compositions for CNS delivery of iduronate-2-sulfatase |
摘要 |
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
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申请公布号 |
US8545837(B2) |
申请公布日期 |
2013.10.01 |
申请号 |
US201113168966 |
申请日期 |
2011.06.25 |
申请人 |
ZHU GAOZHONG;LOWE KRIS;SHAHROKH ZAHRA;CHRISTIAN JAMES;FAHMER RICHARD;PAN JING;WRIGHT TERESA LEAH;CALIAS PERICLES;SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
ZHU GAOZHONG;LOWE KRIS;SHAHROKH ZAHRA;CHRISTIAN JAMES;FAHMER RICHARD;PAN JING;WRIGHT TERESA LEAH;CALIAS PERICLES |
分类号 |
A61K38/46;A61P25/00 |
主分类号 |
A61K38/46 |
代理机构 |
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