摘要 |
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon. |
申请人 |
PFIZER INC. |
发明人 |
DIDIUK, MARY THERESA;TU, MEIHUA MIKE;GUZMAN-PEREZ, ANGEL;ASPNES, GARY ERICK;FILIPSKI, KEVIN JAMES;LEE, ESTHER CHENG YIN;PFEFFERKORN , JEFFREY ALLEN;STEVENS, BENJAMIN DAWSON |