发明名称 |
Bis-pyridino containing compounds for the use in the treatment of CNS pathologies |
摘要 |
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
|
申请公布号 |
US8546415(B2) |
申请公布日期 |
2013.10.01 |
申请号 |
US20100714219 |
申请日期 |
2010.02.26 |
申请人 |
CROOKS PETER A.;DWOSKIN LINDA P.;AYERS JOSHUA;GRINEVICH VLADIMIR;SUMITHRAN SANGEETHA;UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
CROOKS PETER A.;DWOSKIN LINDA P.;AYERS JOSHUA;GRINEVICH VLADIMIR;SUMITHRAN SANGEETHA |
分类号 |
A61K31/435;A61K31/444;A61K31/4709;C07D213/16;C07D213/22;C07D215/10;C07D217/10;C07D401/04;C07D401/14 |
主分类号 |
A61K31/435 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|