发明名称 |
PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS |
摘要 |
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure formula (I) wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
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申请公布号 |
CA2531507(C) |
申请公布日期 |
2013.10.01 |
申请号 |
CA20042531507 |
申请日期 |
2004.07.06 |
申请人 |
NEUROCRINE BIOSCIENCES, INC. |
发明人 |
ZHU, YUN-FEI;REGAN, COLLIN;RUETER, JAIMIE K.;GUO, ZHIQIANG;CHEN, YONGSHENG;HUANG, CHARLES Q. |
分类号 |
C07D239/54;A61K31/506;A61K31/513;A61P5/02;A61P5/04;C07D401/06 |
主分类号 |
C07D239/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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