发明名称 |
TFPI INHIBITORS AND METHODS OF USE |
摘要 |
<p>The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. Peptide complexes also are provided. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.</p> |
申请公布号 |
CA2867363(A1) |
申请公布日期 |
2013.09.26 |
申请号 |
CA20132867363 |
申请日期 |
2013.01.31 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA |
发明人 |
DOCKAL, MICHAEL;HARTMANN, RUDOLF;SCHEIFLINGER, FRIEDRICH;OSTERKAMP, FRANK;POLAKOWSKI, THOMAS;REINEKE, ULRICH |
分类号 |
A61K38/10;A61P7/02;C07K7/08 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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