发明名称 |
METHOD TO OVERCOME DNA CHEMICAL MODIFICATIONS SENSITIVITY OF ENGINEERED TALE DNA BINDING DOMAINS |
摘要 |
The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. Particularly, the present invention reports the characterization of TALE derived proteins that can efficiently target methylated DNA. The present invention more specifically relates to TALE derived proteins that allow activation of methylated promoters responsible for gene silencing. |
申请公布号 |
WO2013140250(A1) |
申请公布日期 |
2013.09.26 |
申请号 |
WO2013IB00721 |
申请日期 |
2013.03.15 |
申请人 |
CELLECTIS |
发明人 |
DUCHATEAU, PHILIPPE;VALTON, JULIEN |
分类号 |
C12N9/10;C12N9/16;C12N9/88;C12N15/10 |
主分类号 |
C12N9/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|