NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS

摘要

Phosphoramidate derivatives of nucleoside compounds of formula I: (see formula I) derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the .beta.-2' position with methyl and the phosphoramidate group, suitably comprises 1-naphthyl linked by -O- to the P atom.