DERIVATIVES OF 1-PHENOXY PROPAN-2-OL AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: A phenoxypropanol derivative is provided to effectively suppress T-type calcium channel or TWIK-related K+ (TREK)-1 channel, thereby treating various diseases caused by the activation of the channels. CONSTITUTION: A phenoxypropanol derivative of chemical formula I or a racemic body, a pharmaceutically acceptable salt, a solvate, or a hydrate thereof is provided. A pharmaceutical composition for preventing or treating diseases related to T-type calcium channel or TREK-1 channel, selected among Parkinson's disease, Alzheimer's disease, schizophrenia, sleep disorder, epilepsy, pain, hypertension, arrhythmia, ventricular hypertrophy, angina pectoris, heart failure, myocardial infarction, cancer, hypoxia, cerebral ischemia, alkalemia, and depression contains the phenoxypropanol derivative, the racemic body, the pharmaceutically acceptable salt, the solvate, or the hydrate as an active ingredient. A method for suppressing T-type calcium channel or TREK-1 channel comprises the steps of: preparing a biological sample from an organ; and applying the phenoxypropanol derivative, the racemic body, the pharmaceutically acceptable salt, the solvate, or the hydrate to the biological sample.