发明名称 |
GPRR-BPB SPECIFICALLY BINDING TO GPCR |
摘要 |
The present invention relates to a GPCR-bipodal peptide binder specifically binding to GPCR, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a GPCR-target binding region I and a GPCR-target binding region II which bind respectively to both ends of the structure stabilizing region and comprise randomly selected n and m amino acids, respectively. The GPCR-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to GPCR, thereby showing very high affinity to a GPCR target. The GPCR-bipodal peptide binder of the present invention has medical use, can be used for in vivo molecular imaging, in vitro cell imaging and targeting for drug delivery, and also can be very usefully used as an escort molecule.
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申请公布号 |
KR20130103300(A) |
申请公布日期 |
2013.09.23 |
申请号 |
KR20127023551 |
申请日期 |
2011.04.20 |
申请人 |
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
JON, SANG YONG;KIM, SUNG HYUN;PARK, SE HO;KIM, DAE JIN;LEE, SANG HEON |
分类号 |
C07K1/107;C12N15/63;C40B30/04;C40B40/10 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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