| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to selective method of introducing fluorine atom into biomolecule. Method includes supply of linker, which contains thiol-reactive end and azido- or alkine-reactive end, interaction of thiol-reactive end of linker with biomolecule, which contains at least one thiol group or thiol group derivative, which can be activated in order to form free thiol group and the following interaction of azido- or alkine-reactive end of linker with fluorine-substituted azide or alkine group, where linker represents:or. Method makes it possible to selectively bind linker to biomolecule and selectively bind fluorine at final stage, which eliminates necessity of additional purification stages.EFFECT: invention also relates to linkers claimed in method.6 cl, 5 dwg, 1 tbl, 9 ex |
