发明名称 |
REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER |
摘要 |
Methods of "reprogramming" epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2. |
申请公布号 |
WO2013127011(A1) |
申请公布日期 |
2013.09.06 |
申请号 |
WO2013CA50145 |
申请日期 |
2013.02.27 |
申请人 |
BRITISH COLUMBIA CANCER AGENCY BRANCH |
发明人 |
JONES, STEVEN J.M.;YAKOVENKO, OLEKSANDR;THOENE, SILVIA;CHEUNG, PIERRE YULMIN;AN, JIANGHONG |
分类号 |
A61K31/135;A61K31/10;A61K31/167;A61K31/245;A61K31/36;A61K31/407;A61K31/5375;A61P35/00;G01N33/53;G01N33/68 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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