| 摘要 |
<p>Provided are a melanocyte-stimulating hormone analogue formed by connecting a circular core sequence and biotin or membrane-penetrating peptide, and the preparation method and use thereof, wherein the melanocyte-stimulating hormone analogue is formed by connecting the functional unit and biotin or membrane-penetrating peptide, and the structure of the functional unit is Arg-c(Asp-Dab-D-Phe-Arg-Trp-Lys), and the structure of the membrane-penetrating peptide is Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg or Arg-Arg-Arg. The melanocyte-stimulating hormone analogue can be absorbed by permeating the mucosa or skin for treatment of male and female sexual dysfunction, obesity and hypo-pigmentation.</p> |
