| 摘要 |
PROBLEM TO BE SOLVED: To provide matrices suitable for local repair and treatment of bone fractures.SOLUTION: A formulation is used for local repair and treatment of bone fractures, which comprises (i) a peptide selected from the group consisting of PTH and a PTH fusion peptide, (ii) a granular material comprising a calcium mineral, and (iii) a composition capable of forming a fibrin matrix under physiological conditions, comprising a fibrinogen precursor component and thrombin precursor component, wherein the PTH or PTH fusion peptide is present in a concentration range of between 0.01 to 2 mg/mL fibrin matrix or precursor components forming the matrix, except the concentration of 0.4 mg/mL fibrin matrix or precursor components forming the matrix. |
