发明名称 |
TREATING BLADDER TUMOR CELLS USING FIBRONECTIN ATTACHMENT PROTEIN AS A TARGET |
摘要 |
Composition and methods are disclosed for utilizing micro-aggregation of FAP-containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum-free conditions such as the ones found in the lumen of the bladder.
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申请公布号 |
US2013230584(A1) |
申请公布日期 |
2013.09.05 |
申请号 |
US201113884427 |
申请日期 |
2011.11.11 |
申请人 |
AGUILAR RUBEN CLAUDIO;RATLIFF TIMOTHY;THOMPSON DAVID;CRIST SCOTT;PURDUE RESEARCH FOUNDATION |
发明人 |
AGUILAR RUBEN CLAUDIO;RATLIFF TIMOTHY;THOMPSON DAVID;CRIST SCOTT |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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