发明名称 URACYL SPIROOXETANE NUCLEOSIDES
摘要 Compounds of the formula I: including any possible stereoisomers thereof, wherein: R 4 is a monophosphate, diphosphate or triphosphate ester; or R 4 is R 7 is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl; R 8 and R 8' are hydrogen, C 1 -C 6 alkyl, benzyl, or phenyl; or R 8 and R 8' form C 3 -C 7 cycloalkyl; R 9 is C 1 -C 10 alkyl, C 3 -C 7 cycloalkyl, phenyl or phenyl-C 1 -C 6 alkyl, wherein the phenyl moiety in phenyl or phenyl-C 1 -C 6 alkyl is optionally substituted; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations and the use of compounds I as HCV inhibitors.
申请公布号 SI2430035(T1) 申请公布日期 2013.08.30
申请号 SI20100030246T 申请日期 2010.05.11
申请人 JANSSEN PRODUCTS, L.P.;MEDIVIR AB 发明人 JONCKERS TIM HUGO MARIA;RABOISSON PIERRE JEAN-MARIE BERNARD;VANDYCK KOEN;VAN HOOF STEVEN MAURICE PAULA;HU LILI;TAHRI ABDELLAH
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