HETEROARENE CARBONYLATED CINCHONA ALKALOID CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE &bgr;-AMINOPHOSPHONIC ACID OR &bgr;-AMINOPHOSPHINE USING THE SAME

摘要

PROBLEM TO BE SOLVED: To achieve efficient asymmetric synthesis of an optically active α,&bgr;-disubstituted &bgr;-aminophosphonic acid and &bgr;-aminophosphine derivative, in view of wide use of an optically active &bgr;-aminophosphonic acid or &bgr;-aminophosphine derivative as an intermediate of the synthesis of agricultural chemicals or pharmaceuticals or an asymmetric ligand.SOLUTION: Phosphite ester is reacted with various kinds of mesoaziridines in the presence of zinc alkyl and an asymmetric ligand, and by asymmetric ring-opening reaction of aziridine, &bgr;-aminophosphonic acid or &bgr;-aminophosphine derivative is synthesized.