| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to production of acidic polysaccharides and can be used in producing cosmetics. The acidic polysaccharides are selected from hyaluronic acid, chondroitin sulphate, dermatan sulphate, heparan sulphate and keratan sulphate and are characterised by simultaneous presence of alcohol groups that are esterified with butyric acid and formic acid. The method of producing said acidic polysaccharides involves dissolving an acidic polysaccharide in form of a salt with sodium or other alkali metals in formamide while heating. Butyric anhydride is then added to the obtained solution at room temperature in the presence of an organic base. The obtained homogeneous viscous reaction mixture is then diluted with aqueous NaCl solution and neutralised to pH 6-7.5. Further, the diluted reaction mixture is purified by dialysis or cross-flow filtration and the purified polysaccharide solution is frozen. The product is recovered by freeze-drying or spray-drying. In the disclosed compounds, presence of butyric acid and formic ester substitutes of a modified polymer protect from enzymatic degradation by hyaluronidases presence if tissue.EFFECT: invention enables to obtain polysaccharides which can be used in cosmetics and medical drugs for local application as moisturising, smoothing and tonic components or as adjuvants when treating skin damages.16 cl, 1 dwg, 1 tbl, 9 ex |
