发明名称 |
METHODS AND COMPOSITION RELATED TO BROWN ADIPOSE-LIKE CELLS |
摘要 |
Methods and therapeutics are provided for treating diseases, including metabolic diseases and other weight-related disorders. Generally, methods for making brown adipose-like including culturing a population of artery-derived cells in adipogenic induction medium for a period of time and under conditions sufficient to increase expression of at least one adipocyte marker at a higher level as compared to untreated artery-derived cells are disclosed. Isolated artery-derived, ex vivo differentiated brown adipose-like cells are also provided, including pharmaceutical compositions and cell delivery systems thereof. In another embodiment, a method of treating a subject is disclosed that includes obtaining a population of artery-derived brown adipose-like cells and administering the brown adipose-like cells into a target region in the subject.
|
申请公布号 |
US2013209418(A1) |
申请公布日期 |
2013.08.15 |
申请号 |
US201313765008 |
申请日期 |
2013.02.12 |
申请人 |
REGENERATIVE THERAPEUTICS, LLC JOHNSON & JOHNSON;JOHNSON & JOHNSON REGENERATIVE THERAPEUTICS, LLC |
发明人 |
SEYDA AGNIESZKA;COLTER DAVID C.;BUENSUCESO CHARITO S.;KAZANECKI CHRISTIAN C.;DHANARAJ SRIDEVI |
分类号 |
C12N5/071;A61K35/12 |
主分类号 |
C12N5/071 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|