COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER
摘要
<p>An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging: (i) an anti-EGFR antibody comprising the CDR sequences of anti EGFR 565 (CNCM Deposit Number I-4262); and (ii) an anti-ErbB-2 antibody comprising the CDR sequences of anti ErbB-2 L431 (CNCM Deposit Number I-4115), anti ErbB-2 L26 (CNCM Deposit Number I- 4113) or anti ErbB-2 N12 (CNCM Deposit Number I-4112), or (iii) an anti-EGFR antibody comprising the CDR sequences of anti EGFR 111 (CNCM Deposit Number I-4261); and (iv) an anti-ErbB-2 antibody comprising the CDR sequences of anti ErbB-2 L431 (CNCM Deposit Number I-4115). Also provided are pharmaceutical compositions and methods of using the above antibodies as well as other antibody combinations for the treatment of cancer.</p>
申请公布号
WO2012156975(A9)
申请公布日期
2013.08.15
申请号
WO2012IL50176
申请日期
2012.05.16
申请人
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;SELA, MICHAEL;YARDEN, YOSEF;SCHECHTER, BILHA;MARON, RUTH