发明名称 |
Oxidized avidin with high residency time in the treated tissues |
摘要 |
The present invention describes chemically modified avidins that have higher permanence in treated tissues compared to wild type avidin. Avidin oxidation is performed by periodate incubation in the presence of the low affinity ligand HABA which, occupying the biotin binding sites, prevents protein denaturation during the oxidation step. Periodate oxidation generates CHO groups from avidin mannose ring opening that, once injected, react with tissue NH |
申请公布号 |
AU2008281901(B2) |
申请公布日期 |
2013.08.15 |
申请号 |
AU20080281901 |
申请日期 |
2008.07.16 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
DE SANTIS, RITA;NUZZOLO, CARLO ANTONIO |
分类号 |
A61K47/42;A61P35/00 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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