POLYHYDROXYLATED MACROLIDES FROM SEIMATOSPORIUM DISCOSIOIDES AND ITS USE

摘要

PURPOSE: Novel polyhydroxylated macrolides which is separated from seimatosporium discosioides is provided to act as an effector of peroxisome proliferator-activated receptor γ, thereby being usefully used for the prevention and treatment of diabetes or inflammation disease etc while minimizing side effects. CONSTITUTION: A pharmaceutical composition for the prevention and treatment of disease which is mediated by a peroxisome proliferator-activated receptor γ (PPAR γ) and characterized by being selected from a group consisting of diabetes, obesity, inflammation disease and cancer includes the extract of seimatosporium discosioides as an active ingredient. A polyhydroxylated macrolides derivative is indicated as a chemical formula 1 or a chemical formula 2.