| 发明名称 |
MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS |
| 摘要 |
PROBLEM TO BE SOLVED: To provide further HER2-directed cancer therapies.SOLUTION: This invention relates to auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), being prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates are active in vitro and in vivo. |
| 申请公布号 |
JP2013151567(A) |
申请公布日期 |
2013.08.08 |
| 申请号 |
JP20130101615 |
申请日期 |
2013.05.13 |
| 申请人 |
SEATTLE GENETICS INC |
发明人 |
DORONINA SVETLANA O;SENTER PETER D;TOKI BRIAN E;EBENS ALLEN J;KLINE TONI BETH;POLAKIS PAUL;SLIWKOWSKI MARK X;SPENCER SUSAN D |
| 分类号 |
C07K5/027;A61K38/00;A61K38/06;A61K39/395;A61K45/00;A61K47/42;A61K47/48;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P37/00;C07K7/50;C07K16/46;C12N15/02;C12N15/09 |
主分类号 |
C07K5/027 |
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