发明名称 |
A CATALYTIC TAGGING SYSTEM TO STUDY MACRO-MOLECULAR INTERACTIONS USING ENGINEERED UBIQUITIN LIGASE AND UBIQUITIN-LIKE PROTEINS TO FACILITATE SUBSTRATE IDENTIFICATION |
摘要 |
<p>The present invention describes an unbiased catalytic tagging system to search for target substrates. Identification of substrates for specific baits is accomplished by utilizing an orthogonal system consisting of an El activating enzyme, an E2 ubiquitin-like conjugating enzyme, and baits that are fused to the E2 ubiquitin-like conjugating enzyme. The present invention thus reveals important mutually antagonistic substrates of specific baits.</p> |
申请公布号 |
WO2013112625(A1) |
申请公布日期 |
2013.08.01 |
申请号 |
WO2013US22800 |
申请日期 |
2013.01.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WELLS, JAMES, A.;ZHUANG, MIN |
分类号 |
C12Q1/00;C12N9/00;C12Q1/25 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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