GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY

摘要

The present invention is directed to a novel class of antimicrobial agents called gamma- AApeptides. The current invention provides various categories of gamma-AApeptides, for example, linear gamma-AApeptides, cyclic gamma-AApeptides, and lipidated gamma-AApeptides. gamma- AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. y-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed gamma-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.