摘要 |
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds. |
申请人 |
BANNEN LYNNE CANNE;CHAN DIVA SZE-MING;CHEN JEFF;DALRYMPLE LISA ESTHER;FORSYTH TIMOTHY PATRICK;HUYNH TAI PHAT;JAMMALAMADAKA VASU;KHOURY RICHARD GEORGE;LEAHY JAMES WILLIAM;MAC MORRISON B.;MANN GRACE;MANN LARRY W.;NUSS JOHN M.;PARKS JASON JEVIOUS;TAKEUCHI CRAIG STACY;WANG YONG;XU WEI;EXELIXIS, INC. |
发明人 |
BANNEN LYNNE CANNE;CHAN DIVA SZE-MING;CHEN JEFF;DALRYMPLE LISA ESTHER;FORSYTH TIMOTHY PATRICK;HUYNH TAI PHAT;JAMMALAMADAKA VASU;KHOURY RICHARD GEORGE;LEAHY JAMES WILLIAM;MAC MORRISON B.;MANN GRACE;MANN LARRY W.;NUSS JOHN M.;PARKS JASON JEVIOUS;TAKEUCHI CRAIG STACY;WANG YONG;XU WEI |