发明名称 |
Delivery of nucleic acid-like compounds |
摘要 |
A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component ("PFC") and a nucleic acid-like component ("NAC") in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.
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申请公布号 |
US8496961(B2) |
申请公布日期 |
2013.07.30 |
申请号 |
US20030439856 |
申请日期 |
2003.05.15 |
申请人 |
HONG KEELUNG;ZHENG WEI-WEN;DRUMMOND DARYL C.;KIRPOTIN DMITRI B.;HAYES MARK EAMON;SUTTER WEST BAY HOSPITAL |
发明人 |
HONG KEELUNG;ZHENG WEI-WEN;DRUMMOND DARYL C.;KIRPOTIN DMITRI B.;HAYES MARK EAMON |
分类号 |
A61K9/127;C12N15/09;A61K9/22;A61K9/32;A61K9/51;A61K31/7088;A61K47/14;A61K47/24;A61K47/28;A61K47/34;A61K48/00;C12N;C12N5/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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