发明名称 |
Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases |
摘要 |
The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
|
申请公布号 |
US8497294(B2) |
申请公布日期 |
2013.07.30 |
申请号 |
US201113180127 |
申请日期 |
2011.07.11 |
申请人 |
WOODHEAD STEVEN JOHN;REES DAVID CHARLES;GRIMSHAW KYLA MERRIOM;ASTEX THERAPEUTICS LIMITED;THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL;CANCER RESEARCH TECHNOLOGY LIMTIED |
发明人 |
WOODHEAD STEVEN JOHN;REES DAVID CHARLES;GRIMSHAW KYLA MERRIOM |
分类号 |
A61K31/415;C07D231/12 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|