发明名称 |
COMPOUNDS FOR TARGETED PREPARATION DELIVERY TO TISSUE OR TARGETED ORGAN |
摘要 |
The invention provides a compound comprising a target specific portion and an effector portion wherein the target specific portion comprises or consists of a monoclonal antibody having specificity for oncofoetal fibronectin, or a fragment or variant thereof which retains the antigen binding specificity of the parent monoclonal antibody and the effector portion comprises or consists of interleukin-12, or a functional fragment or variant thereof, characterised in the monoclonal antibody having specificity for oncofoetal fibronectin binds to a region of oncofoetal fibronectin other than the ED-B region. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, e.g. in the treatment of cancer. |
申请公布号 |
EA011859(B9) |
申请公布日期 |
2013.07.30 |
申请号 |
EA20060001264 |
申请日期 |
2005.01.05 |
申请人 |
EMD LEXIGEN RESEARCH CENTER CORP.;ANTISOMA PLC |
发明人 |
GILLIES STEPHEN;LO KIN-MING;LAN YAN;VERMA RAKESH |
分类号 |
C12N15/62;A61K47/48;A61P35/00;C07K14/54;C07K16/24;C07K16/30 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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