| 摘要 |
FIELD: chemistry.SUBSTANCE: disclosed is (carboxylalkylenephenyl)phenyloxamides of formula, where R3 denotes H, F, Cl, Br, CF, phenyl, COOH, COO-(C-C)-alkyl, (C-C)-alkyl, (C-C)-cycloalkyl, wherein the phenyl can be monosubstituted with: R12; R1, R5 independently denote H, F, Cl, Br, CF, phenyl, COOH, COO-(C-C)-alkyl, (C-C)-alkyl; R2, R4 independently denote H, F, Cl, Br, CF; R7, R8, independently denote H or (C-C)-alkyl; X denotes (C-C)-alkylene, which can be monosubstituted or multisubstituted with R11; m equals 0; R6 denotes OH, F, Cl, Br, CN, OCH; OCF, CH, CF, (C-C)-alkyl or O-(C-C)-alkyl, and the alkyl can be monosubstituted or multisubstituted with OH, F, Cl, Br or CN; R11 denotes (C-C)-alkynyl; R12 denotes (C-C)-alkyl; and physiologically acceptable salts thereof.EFFECT: disclosed compounds have activity towards the GPR40 receptor and are suitable for preparing a medicinal agent for reducing blood sugar level, treating diabetes, increasing insulin release, treating diseases of the central nervous system, treating schizophrenia and Alzheimer's disease.19 cl, 2 tbl, 35 ex |
