发明名称 |
ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN SIGLEC-15 |
摘要 |
PROBLEM TO BE SOLVED: To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism.SOLUTION: There are provided a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like. |
申请公布号 |
JP2013144708(A) |
申请公布日期 |
2013.07.25 |
申请号 |
JP20130080007 |
申请日期 |
2013.04.05 |
申请人 |
DAIICHI SANKYO CO LTD |
发明人 |
HIRUMA YOSHIHARU;TSUDA HIDEYORI |
分类号 |
C07K16/28;A61K39/395;A61K45/00;A61P19/02;A61P19/08;A61P19/10;A61P29/00;A61P35/00;C07K16/46;C12N5/10;C12N15/02;C12N15/09;C12P21/08 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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