发明名称 |
Monoclonal antibody capable of binding to specific discontinuous epitope occurring in AD1 region of human cytomegalovirus GB glycoprotein, and antigen-binding fragment thereof |
摘要 |
The present invention provides a pharmaceutical composition for human cytomegalovirus HCMV causative of various disease states, the composition comprising a monoclonal antibody and an antigen-binding fragment thereof that specifically binds to the AD1 region of glycoprotein gB and that has excellent neutralizing capacity. The present invention provides: a monoclonal antibody and an antigen-binding fragment thereof having an excellent neutralizing capacity and cell-to-cell infection blocking capacity and specifically binding to a discontinuous sequence occurring in the HCMV AD1 region; a pharmaceutical composition comprising the antibody or the fragment thereof; and the like.
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申请公布号 |
US8492529(B2) |
申请公布日期 |
2013.07.23 |
申请号 |
US201013262061 |
申请日期 |
2010.04.01 |
申请人 |
TAKADA KENZO;KURINO RIKA;TORASHIMA TAKASHI;EVEC INCORPORATED |
发明人 |
TAKADA KENZO;KURINO RIKA;TORASHIMA TAKASHI |
分类号 |
C07K16/00;A61K39/395;A61K39/42 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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