ANTIBODIES AGAINST HUMAN IL-12

摘要

PROBLEM TO BE SOLVED: To provide human IL-12 antibodies that has a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies.SOLUTION: The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity, thereby making them useful IL-12 antagonists.