摘要 |
Substituted bicyclic beta-lactams of Formula I: (I), are beta-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with beta-lactam antibiotics. In particular, the compounds can be employed with a beta-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to beta-lactam antibiotics due to the presence of the beta-lactamases.
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