| 摘要 |
The invention relates to a combination which comprises a DPP-IV inhibitor which is (S)-1-[(3-hydroxy-1--adamantyl)amino]acetyl-2-cyano-pyrrolidine, in free form or in acid addition salt form, and metformin or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of conditions mediated by dipeptidylpeptidase-IV (DPP-IV), in particular diabetes, more especially type 2 diabetes mellitus, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, metabolic acidosis, ketosis, arthritis, obesity and osteoporosis; and the use of such combination for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight.
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