GENDER-SPECIFIC IDENTIFICATION OF SPERM CELLS AND EMBRYOS USING LOCKED NUCLEIC ACIDS

摘要

Disclosed are sperm cells and embryos comprising a labeled locked nucleic acid bound to a gender-specific repeat sequence. Methods for identifying and separating sperm cells or embryos containing a labeled locked nucleic acid from sperm cells or embryos not containing the labeled oligonucleotide produce gender-enriched sperm cell or embryo fractions. The separated fractions are useful in producing offspring of a predetermined sex.