| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for efficiently producing optically-active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane in a high yield from otpically-active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol while maintaining high optical purity, and further producing an otpically-active material of [3,5-bis(trifluoromethyl)phenyl]ethane derivative.SOLUTION: The method for producing an optically-active material of 1-[3,5-bis(trifluoromethyl)phenyl]ethane derivative includes the step of obtaining optically-active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane by brominating optically-active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by use of, as a brominating agent, (a) a combination of phosphor halide and hydrogen bromide; (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphor compound represented by general formula (4) P(R)(R)(R) (R, Rand Reach represent 6-10C aryl); or (c) a combination of N-bromosuccinimide and dialkyl sulfide. |
